Ganoderma lucidum/ ריישי/ Ling Zhi

פטריית הריישי התפרסמה כאחת מפטריות הכוח היפניות, וניתן לומר כי היא המובילה מבינהן בהיקף ההשפעות שלה ובהיקף עבודות המחקר המודרני שנעשו עליה.

לפטרייה מיוחסת השפעה המחזקת את פעילות מערכת החיסון (1,2) השפעה נוגדת דלקת(3), השפעה המיטיבה עם חולים במחלות ממאירות (4-8), הפחתת רמות סוכר (9-12) ושומני דם (13), השפעה המיטיבה עם טרשת עורקים(14), השפעה נוגדת חמצון (15-17) השפעה המגנה על מערכת העצבים(18), השפעה המגינה על הכבד (19-23), תומכת בסובלים מהגדלה שפירה של הערמונית (24), משפרת פוריות ותפקוד מיני זכרי(25), השפעה נוגדת אלרגיה ודלקת (26) ועוד.

פטריית הריישי ידועה כאחד מהחומרים המובילים לתמיכה בחולים אונקולוגים (28-35).

הפטרייה נחשבת לבטוחה לשימוש והתאקלמה היטב בישראל. עם זאת יש לנקוט זהירות בעת השימוש בקרב אנשים הנוטלים תרופות נוגדות קרישה, תרופות שמטרתן לדכא את פעילות מערכת החיסון, וכמו כן יש להיזהר בשימוש בעת נטילה של תרפות מרגיעות ומשרות שינה, תרופות להורדת סוכר ולחץ דם, תרופות אנטיביוטיות מסויימות ותרופות כימותרפיות מסויימות.

אפיקסייפ.jpeg
ניתן לבדוק אינטראקציות בין צמחים לבין תרופות באתר 

למען הסר ספק המידע אינו  מהווה המלצה רפואית מוסמכת ואינו מיועד להנחות את הציבור או לשמש לגביו כהמלצה או הוראה או עצה לשימוש או שינוי או הורדה של תרופה כלשהי, ואין בו תחליף לייעוץ רפואי פרטני או אחר.

המונח ‘צמחי מרפא’ מתייחס להגדרה המקובלת ברפואת הצמחים המסורתית וברפואה המשלימה.

1. Effects of polysaccharide from mycelia of Ganoderma lucidum on intestinal barrier functions of rats. Mingliang Jin, Yimin Zhu , Dongyan Shao , Ke Zhao , Chunlan Xu , Qi Li , Hui Yang , Qingsheng Huang , Junling Shi. s.l. : Int J Biol Macromol, 2017.

https://pubmed.ncbi.nlm.nih.gov/27693834/

2. Response of intestinal metabolome to polysaccharides from mycelia of Ganoderma lucidum. Mingliang Jin, Hao Zhang , Jiaojiao Wang , Dongyan Shao , Hui Yang , Qingsheng Huang , Junling Shi , Chunlan Xu , Ke Zhao. s.l. : Int J Biol Macromol, 2019.

https://pubmed.ncbi.nlm.nih.gov/30395901/

3. Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice. Yu-Sheng Chen, Quan-Zhan Chen , Zhen-Jiong Wang , Chun Hua. s.l. : Pharmacology, 2019.

https://pubmed.ncbi.nlm.nih.gov/30673679/

4. Ling-Zhi polysaccharides potentiate cytotoxic effects of anticancer drugs against drug-resistant urothelial carcinoma cells. Chao-Yuan Huang, Jeff Yi-Fu Chen, Jia-En Wu, Yeong-Shiau Pu, Guang-Yaw Liu, Min-Hsiung Pan, Ying-Tang Huang, A-Mei Huang, Chi-Ching Hwang, Shu-Ju Chung, Tzyh-Chyuan Hour. s.l. : J Agric Food Chem, 2010.

https://pubmed.ncbi.nlm.nih.gov/20681668/

5. Improved antitumor activity of cisplatin combined with Ganoderma lucidum polysaccharides in U14 cervical carcinoma-bearing mice. Jun Zhu, Jia Xu , Ling-Ling Jiang , Jin-Qun Huang , Jin-Yu Yan , Yi-Wan Chen , Qian Yang. s.l. : Kaohsiung J Med Sci, 2019 .

https://pubmed.ncbi.nlm.nih.gov/30958641/

6. Effects of the polysaccharides extracted from Ganoderma lucidum on chemotherapy-related fatigue in mice. Ming-Zi Ouyang, Li-Zhu Lin , Wen-Jiao Lv , Qian Zuo , Zhuo Lv , Jie-Shan Guan , Shu-Tang Wang , Ling-Ling Sun , Han-Rui Chen , Zhi-Wei Xiao. s.l. : Int J Biol Macromol, 2016.

https://pubmed.ncbi.nlm.nih.gov/27208798/

7. Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin. Sufen Zhao, Gang Ye, Guodong Fu, Jian-Xin Cheng, Burton B Yang, Chun Peng. s.l. : Int J Oncol, 2011.

https://pubmed.ncbi.nlm.nih.gov/21399867/

8. Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin. Xiangyang Yao, Guilan Li, Hui Xu, Chaotian Lü. s.l. : Planta Med, 2012 .

https://pubmed.ncbi.nlm.nih.gov/22961117/

9. Ganoderma lucidum polysaccharides improve insulin sensitivity by regulating inflammatory cytokines and gut microbiota composition in mice. S.Xu, Y.Dou, Yec,Q.Wu,Y.Wang,M.Hu,F.Ma,X.Rong,J.Guo. s.l. : Journal of Functional Foods, 2017.

https://www.sciencedirect.com/science/article/abs/pii/S1756464617305534

10. Antihyperglycemic Effect of Ganoderma Lucidum Polysaccharides on Streptozotocin-Induced Diabetic Mice. Fenglin Li, Yiming Zhang, Zhijian Zhong. s.l. : Int J Mol Sci., 2011.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189773/

11. Ganoderma lucidum polysaccharides exert anti-hyperglycemic effect on streptozotocin-induced diabetic rats through affecting β-cells. Jusheng Zheng, Bin Yang, Yinghua Yu, Qi Chen, Tao Huang, Duo Li. s.l. : Comb Chem High Throughput Screen, 2012.

https://pubmed.ncbi.nlm.nih.gov/22329512/

12. Hypoglycemic effect and mechanism of a proteoglycan from ganoderma lucidum on streptozotocin-induced type 2 diabetic rats. B S Teng, C D Wang, D Zhang, J S Wu, D Pan, L F Pan, H J Yang, P Zhou. s.l. : Eur Rev Med Pharmacol Sci, 2012.

https://pubmed.ncbi.nlm.nih.gov/22428467/

13. Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs. A Berger, D Rein, E Kratky, I Monnard, H Hajjaj, I Meirim, C Piguet-Welsch, J Hauser, K Mace, P Niederberger. s.l. : Lipids Health Dis, 2004.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC385249/

14. Effects of Ganoderma lucidum polysaccharides on advanced glycation end products and receptor of aorta pectoralis in T2DM rats. Yang Chen, Jin Qiao, Jia Luo, Feng Wu, Guoliang Meng, Hui Chen, Huihua Zheng, Jiliang Xu. s.l. : Zhongguo Zhong Yao Za Zhi, 2011.

https://pubmed.ncbi.nlm.nih.gov/21657085/

15. Ganoderma lucidum extract protects DNA from strand breakage caused by hydroxyl radical and UV irradiation. K C Kim, I G Kim. s.l. : Int J Mol Med, 1999.

https://pubmed.ncbi.nlm.nih.gov/10425278/

16. Mushroom-derived preparations in the prevention of H2O2-induced oxidative damage to cellular DNA. Yu-ling Shi, Anthony E James, Iris F F Benzie, John A Buswell. s.l. : Teratog Carcinog Mutagen, 2002.

https://pubmed.ncbi.nlm.nih.gov/11835288/

17. Effects of Concurrently Administered Aqueous Extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), and Lead Acetate in Rats. Michael T Sobowale, Raymond I Ozolua , Dickson O Uwaya , Buniyamin A Ayinde.

https://pubmed.ncbi.nlm.nih.gov/30806221/

18. Pharmacological effects of natural Ganoderma and its extracts on neurological diseases: A comprehensive review. Chen Zhao, Chunchen Zhang , Zheng Xing , Zeeshan Ahmad , Jing-Song Li , Ming-Wei Chang. s.l. : Int J Biol Macromol, 2019.

https://pubmed.ncbi.nlm.nih.gov/30342128/

19. Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice. Guo-Liang Zhang, Ye-Hong Wang, Wei Ni, Hui-Ling Teng, Zhi-Bin Lin. s.l. : World J Gastroenterol, 2002 .

https://pubmed.ncbi.nlm.nih.gov/12174387/

20. Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice. Yu-Sheng Chen, Quan-Zhan Chen , Zhen-Jiong Wang , Chun Hua. s.l. : Pharmacology, 2019.

https://pubmed.ncbi.nlm.nih.gov/30673679/

21. Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes. Bin Li, Dong-Sung Lee, Yue Kang, Nai-Qi Yao, Ren-Bo An, Youn-Chul Kim. s.l. : Food Chem Toxicol, 2013.

https://pubmed.ncbi.nlm.nih.gov/23266269/

22. Antimutagenic activity of methanolic extract of Ganoderma lucidum and its effect on hepatic damage caused by benzo[a]pyrene. B Lakshmi, T A Ajith, Nayana Jose, K K Janardhanan. s.l. : J Ethnopharmacol, 2006.

https://pubmed.ncbi.nlm.nih.gov/16713154/

23. Radical scavenger and antihepatotoxic activity of Ganoderma formosanum, Ganoderma lucidum and Ganoderma neo-japonicum. J M Lin, C C Lin, M F Chen, T Ujiie, A Takada. s.l. : J Ethnopharmacol, 1995.

https://pubmed.ncbi.nlm.nih.gov/7564419/

24. Ganoderma lucidum is an inhibitor of testosterone-induced prostatic hyperplasia in rats. A Nahata, V K Dixit. s.l. : Andrologia, 2012.

https://pubmed.ncbi.nlm.nih.gov/21651601/

25. Evaluation of aphrodisiac activity of ethanol extract of Ganoderma lucidum in male Wistar rats. Hammad Ahmed, Muhammad Aslam. s.l. : Clinical Phytoscience 4(1), 2018.

https://www.proquest.com/openview/c28a740b5cc32315ec1cef87b12d3b87/1?pq-origsite=gscholar&cbl=2044309

26. Immunomodulatory activity of Ganoderma lucidum immunomodulatory protein via PI3K/Akt and MAPK signaling pathways in RAW264.7 cells. Qi-Zhang Li, Yu-Zhou Chang , Zhu-Mei He , Lei Chen , Xuan-Wei Zhou. s.l. : J Cell Physiol, 2019.

https://pubmed.ncbi.nlm.nih.gov/31148200/

27. Ganoderma Lucidum has immunostimulatory and antinflamatory effect in breast cancer patients. R. Othman, H.A. Saeed, N. Abdulkade. s.l. : OncologyPRO, 2017.

https://www.annalsofoncology.org/article/S0923-7534(19)55983-X/fulltext

28. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Hong Zhao, Qingyuan Zhang, Ling Zhao, Xu Huang, Jincai Wang, Xinmei Kang. s.l. : Evid Based Complement Alternat Med, 2012.

https://pubmed.ncbi.nlm.nih.gov/22203880/

29. A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas. Shiro Oka, Shinji Tanaka, Shigeto Yoshida, Toru Hiyama, Yoshitaka Ueno, Masanori Ito, Yasuhiko Kitadai, Masaharu Yoshihara, Kazuaki Chayama. s.l. : Hiroshima J Med Sci, 2010.

https://pubmed.ncbi.nlm.nih.gov/20518254/

30. Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer. Xiao Chen, Ze-Ping Hu, Xiao-Xia Yang, Min Huang, Yihuai Gao, Wenbo Tang, Sui Yung Chan, Xihu Dai, Jinxian Ye, Paul Chi-Liu Ho, Wei Duan, Hong-Yuan Yang, Yi-Zhun Zhu, Shu-Feng Zhou. s.l. : Int Immunopharmacol, 2006.

https://pubmed.ncbi.nlm.nih.gov/16428086/

31. Effects of water-soluble Ganoderma lucidum polysaccharides on the immune functions of patients with advanced lung cancer. Yihuai Gao, Wenbo Tang, Xihu Dai, He Gao, Guoliang Chen, Jinxian Ye, Eli Chan, Hwee Ling Koh, Xiaotian Li, Shufeng Zhou. s.l. : J Med Food, 2005.

https://pubmed.ncbi.nlm.nih.gov/16117607/

32. Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Yihuai Gao, Shufeng Zhou, Wenqi Jiang, Min Huang, Xihu Dai. s.l. : Immunol Invest, 2003.

https://pubmed.ncbi.nlm.nih.gov/12916709/

33. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Xingzhong Jin, Julieta Ruiz Beguerie, Daniel Man-Yeun Sze, Godfrey C F Chan. s.l. : Cochrane Database Syst Rev, 2012.

https://pubmed.ncbi.nlm.nih.gov/22696372/

34. A Summary of a Cochrane Review: Ganoderma lucidum (Reishi mushroom) for the treatment of cancer. Nancy Santesso, L Susan Wieland. s.l. : Eur J Integr Med, 2016.

https://pubmed.ncbi.nlm.nih.gov/28083078/

35. Anti-cancer properties of triterpenoids isolated from Ganoderma lucidum - a review. Guo-Sheng Wu, Jia-Jie Guo, Jiao-Lin Bao, Xi-Wen Li, Xiu-Ping Chen, Jin-Jian Lu, Yi-Tao Wang. s.l. : Expert Opin Investig Drugs, 2013.

https://pubmed.ncbi.nlm.nih.gov/23790022/

36. Pharmacological effects of natural Ganoderma and its extracts on neurological diseases: A comprehensive review. Chen Zhao, Chunchen Zhang , Zheng Xing , Zeeshan Ahmad , Jing-Song Li , Ming-Wei Chang. s.l. : Int J Biol Macromol, 2009.

https://pubmed.ncbi.nlm.nih.gov/30342128/

עריכת מקורות: אלה ירושלמי