Glycyrrhiza/ Licorice/ שוש/ Gan Cao

1. M.D, Rudolf Fritz Weiss. Herbal Medicine, Classic Edition. 2001.

https://books.google.co.il/books/about/Weiss_s_Herbal_Medicine.html?id=gDLIrCv26hkC&redir_esc=y

 

2. Grapefruit juice and licorice increase cortisol availability in patients with Addison's disease. Paal Methlie, Eystein E S Husebye, Steinar Hustad, Ernst A Lien, Kristian Løvås. s.l. : Eur J Endocrinol, 2011.

https://pubmed.ncbi.nlm.nih.gov/21896619/

 

3. Licorice ameliorates postural hypotension caused by diabetic autonomic neuropathy. A Basso, L Dalla Paola, G Erle, M Boscaro, D Armanini. s.l. : Diabetes Care, 1994.

https://pubmed.ncbi.nlm.nih.gov/7821181/

 

4. Inhibition of bone marrow-derived dendritic cell maturation by glabridin. Jee Youn Kim, Jong Soon Kang, Hwan Mook Kim, Hwa Sun Ryu, Hyung Sook Kim, Hong Kyung Lee, Yeon Jin Kim, Jin Tae Hong, Youngsoo Kim, Sang-Bae Han. s.l. : Int Immunopharmacol, 2010 .

https://pubmed.ncbi.nlm.nih.gov/20633530/

 

5. Licochalcone A, a Polyphenol Present in Licorice, Suppresses UV-Induced COX-2 Expression by Targeting PI3K, MEK1, and B-Raf. Nu Ry Song, Jong-Eun Kim, Jun Seong Park,Jong Rhan Kim, Heerim Kang, Eunjung Lee,Young-Gyu Kang,Joe Eun Son, Sang Gwon Seo, Yong Seok Heo, and Ki Won Lee. s.l. : Int J Mol Sci, 2015.

https://pubmed.ncbi.nlm.nih.gov/25710724/

 

6. The anti-inflammatory activity of licorice, a widely used Chinese herb. Rui Yang, Bo-Chuan Yuan , Yong-Sheng Ma , Shan Zhou , Ying Liu. s.l. : Pharm Biol, 2017.

https://pubmed.ncbi.nlm.nih.gov/27650551/

 

7. Glabridin inhibits lipopolysaccharide-induced activation of a microglial cell line, BV-2, by blocking NF-kappaB and AP-1. Sun Hong Park, Jong Soon Kang, Yeo Dae Yoon, Kiho Lee, Kang-Jeon Kim, Ki Hoon Lee, Chang Woo Lee, Eun-Yi Moon, Sang-Bae Han, Bong Hee Kim, Hwan Mook Kim, Song-Kyu Park. s.l. : Phytother Res, 2010.

https://pubmed.ncbi.nlm.nih.gov/19455572/

 

8. Anti-inflammatory effect of roasted licorice extracts on lipopolysaccharide-induced inflammatory responses in murine macrophages. Jin-Kyung Kim, Sun-mee Oh, Hyuck-Se Kwon, Yang-Seok Oh, Soon Sung Lim, Hyun-Kyung Shin. s.l. : Biochem Biophys Res Commun, 2006 .

https://pubmed.ncbi.nlm.nih.gov/16716255/

 

9. Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock. Jong Soon Kang, Yeo Dae Yoon, Ig Jun Cho, Mi Hwa Han, Chang Woo Lee, Song-Kyu Park, Hwan Mook Kim.

https://pubmed.ncbi.nlm.nih.gov/15537821/

 

10. Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats. Chun Zhan, Jing Yang. s.l. : Pharmacol Res, 2006.

https://pubmed.ncbi.nlm.nih.gov/16459097/

 

11. Liquiritin modulates ERK‑ and AKT/GSK‑3β‑dependent pathways to protect against glutamate‑induced cell damage in differentiated PC12 cells. Lesheng Teng, Qingfan Meng , Jiahui Lu , Jing Xie , Zhenzuo Wang , Yan Liu , Di Wang. s.l. : Mol Med Rep, 2014.

https://pubmed.ncbi.nlm.nih.gov/24888902/

 

12. In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice). Xue-Qing Yu, Charlie Changli Xue, Zhi-Wei Zhou, Chun-Guang Li, Yao-Min Du, Jun Liang, Shu-Feng Zhou. s.l. : Life Sci, 2008.

https://pubmed.ncbi.nlm.nih.gov/18048062/

 

13. Treatment of chronic hepatitis C virus infection via antioxidants: results of a phase I clinical trial. Alla Melhem, Mirela Stern, Oren Shibolet, Eran Israeli, Zvi Ackerman, Orit Pappo, Nilla Hemed, Mina Rowe, Hana Ohana, George Zabrecky, Robert Cohen, Yaron Ilan. s.l. : J Clin Gastroenterol, 2005.

https://pubmed.ncbi.nlm.nih.gov/16082287/

 

14. Short-term efficacy of treating hepatitis B virus-related acute-on-chronic liver failure based on cold pattern differentiation with hot herbs: A randomized controlled trial. Yu-Ming Guo, Feng-Yi Li , Man Gong , Lin Zhang , Jia-Bo Wang , Xiao-He Xiao , Jun Li , Yan-Ling Zhao , Li-Fu Wang , Xiao-Feng Zhang. s.l. : Chin J Integr Med, 2016.

https://pubmed.ncbi.nlm.nih.gov/27220737/

 

15. Long-term treatment of chronic hepatitis C with glycyrrhizin [stronger neo-minophagen C (SNMC)] for preventing liver cirrhosis and hepatocellular carcinoma. Kumada, Hiromitsu. s.l. : Oncology, 2002.

https://pubmed.ncbi.nlm.nih.gov/11868794/

 

16. Licorice flavonoid oil reduces total body fat and visceral fat in overweight subjects: A randomized, double-blind, placebo-controlled study. Yuji Tominaga, Kaku Nakagawa , Tatsumasa Mae , Mitsuaki Kitano , Shinichi Yokota , Toshihiro Arai , Hideyuki Ikematsu , Shuji Inoue. s.l. : Obes Res Clin Pract, 2009.

https://pubmed.ncbi.nlm.nih.gov/24345587/

 

17. Glycyrrhizic Acid Attenuates the Expression of HMG-CoA Reductase. Maurya S. K., Srivastava A. K. s.l. : Prague Medical Report, 2011.

https://pubmed.ncbi.nlm.nih.gov/21470496/

 

18. Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet-induced obese rats. Chia Hui Apphia Eu, Wai Yen Alfred Lim, So Ha Ton, Khalid bin Abdul Kadir. s.l. : Lipids Health Dis, 2010 .

https://pubmed.ncbi.nlm.nih.gov/20670429/

 

19. Effects of Glycyrrhizic Acid on Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma), Lipoprotein Lipase (LPL), Serum Lipid and HOMA-IR in Rats. Chia Yoke Yin, Ton So Ha, Khalid Abdul Kadir. s.l. : PPAR Res, 2010.

https://pubmed.ncbi.nlm.nih.gov/20011054/

 

20. Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats. Wai Yen Alfred Lim, Yoke Yin Chia, Shih Yeen Liong, So Ha Ton, Khalid Abdul Kadir, Sharifah Noor Akmal Syed Husain. s.l. : Lipids Health Dis, 2009.

https://pubmed.ncbi.nlm.nih.gov/19638239/

 

21. The pentacyclic triterpenoids in herbal medicines and their pharmacological activities in diabetes and diabetic complications. A Alqahtani, K Hamid, A Kam, K H Wong, Z Abdelhak, V Razmovski-Naumovski, K Chan, K M Li, P W Groundwater, G Q Litions. s.l. : Curr Med Chem, 2013.

https://pubmed.ncbi.nlm.nih.gov/23210780/

 

22. Ameliorative effects of glycyrrhizin on streptozotocin-induced diabetes in rats. Subhrojit Sen, Moumita Roy, Abhay Sankar Chakraborti. s.l. : J Pharm Pharmacol, 2011.

https://pubmed.ncbi.nlm.nih.gov/21235594/

 

23. Antidiabetic effect of glycyrrhizin in genetically diabetic KK-Ay mice. H Takii, T Kometani, T Nishimura, T Nakae, S Okada, T Fushiki. s.l. : Biol Pharm Bull, 2001.

https://pubmed.ncbi.nlm.nih.gov/11379765/

 

24. Amelioration of glucose homeostasis by glycyrrhizic acid through gluconeogenesis rate-limiting enzymes. Yoke Yin Chia, Shih Yeen Liong, So Ha Ton, Khalid Bin Abdul Kadir. s.l. : Eur J Pharmacol, 2012.

https://pubmed.ncbi.nlm.nih.gov/22227336/

 

25. Antihyperglycemic effect of 18 beta-glycyrrhetinic acid, aglycone of glycyrrhizin, on streptozotocin-diabetic rats. Panneerselvam Kalaiarasi, Kodukkur Viswanathan Pugalendi. s.l. : Eur J Pharmacol, 2009.

https://pubmed.ncbi.nlm.nih.gov/19374864/

 

26. Estrogenic Substances from Plants: I. Glycyrrhiza. Christopher H. Costello, E V LYNN. s.l. : Journal of the American Pharmaceutical Association , 2006.

https://jpharmsci.org/article/S0095-9553(15)31841-2/fulltext

 

27. Preventive Effect of Glycyrrhiza Glabra Extract on Oral Mucositis in Patients Under Head and Neck Radiotherapy: A Randomized Clinical Trial. Shamsolmolok Najafi, Soraiya Ebrahimpour Koujan , Soheila Manifar , Mohammad Javad Kharazifard , Saba Kidi , Samira Hajheidary. s.l. : J Dent (Tehran), 2017.

https://pubmed.ncbi.nlm.nih.gov/29296112/

 

28. Protective effect of Yashtimadhu (Glycyrrhiza glabra) against side effects of radiation/chemotherapy in head and neck malignancies. Debabrata Das, S K Agarwal, H M Chandola. s.l. : Ayu, 2011.

https://pubmed.ncbi.nlm.nih.gov/22408302/

 

29. Glycyrrhetinic acid potently suppresses breast cancer invasion and metastasis by impairing the p38 MAPK-AP1 signaling axis. Xiu-Feng Wang, Qian-Mei Zhou, Yi-Yu Lu, Hui Zhang, Shuang Huang, Shi-Bing Su. s.l. : Expert Opin Ther Targets, 2015.

https://pubmed.ncbi.nlm.nih.gov/25828376/

 

30. Studies on the identification of constituents in ethanol extract of Radix Glycyrrhizae and their anticancer activity. Xiaoli Shi, Ming Zou , Jing He , Hai Xie , Xu Li. s.l. : Afr J Tradit Complement Altern Med, 2014.

https://pubmed.ncbi.nlm.nih.gov/25435618/

 

31. Effect of preoperative licorice lozenges on incidence of postextubation cough and sore throat in smokers undergoing general anesthesia and endotracheal intubation. Diyva Gupta, Sanjay Agrawal, Jagdish P Sharma. s.l. : Middle East J Anaesthesiol, 2013.

https://pubmed.ncbi.nlm.nih.gov/24180166/

 

32. An evaluation of the efficacy of licorice gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study. Anil Agarwal, Devendra Gupta, Ghanshyam Yadav, Puneet Goyal, Prabhat K Singh, Uttam Singh. s.l. : Anesth Analg, 2009.

https://pubmed.ncbi.nlm.nih.gov/19535697/

 

33. Natural anti-inflammatory products and leukotriene inhibitors as complementary therapy for bronchial asthma. Maha E Houssen, Amany Ragab, Abeer Mesbah, Ayman Z El-Samanoudy, Gamal Othman, Amal F Moustafa, Farid A Badria. s.l. : Clin Biochem, 2010.

https://pubmed.ncbi.nlm.nih.gov/20430018/

 

34. interferon therapy in hepatitis C virus (HCV) induced chronic hepatitis: clinical significance of pretreatment with glycyrhizine. Fujisawa, K. s.l. : Trop Gastroenterol, 1991.

https://www.researchgate.net/publication/21429817_Interferon_therapy_in_hepatitis_C_virus_HCV_induced_chronic_hepatitis_clinical_significance_of_pretreatment_with_glycyrhizine

 

35. Glycyrrhizin enhances interleukin-12 production in peritoneal macrophages. Ji Hong Dai, Yasumasa Iwatani,Takaomi Ishida, Hiroshi Terunuma, Hirotake Kasai, Yoichiro Iwakula, Hiromi Fujiwara, and Masahiko Ito. s.l. : Immunology, 2001.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783229/

 

36. Treatment of chronic hepatitis B. Part 2: Effect of glycyrrhizic acid on the course of illness. Eisenburg, J. s.l. : Fortschr Med, 1992.

https://pubmed.ncbi.nlm.nih.gov/1516877/

 

37. Glycyrrhizin gel as a vehicle for idoxuridine. R Segal, S Pisanty. s.l. : J Clin Pharm Ther, 1987.

https://pubmed.ncbi.nlm.nih.gov/3611213/

 

38. Antibacterial Effect and Mode of Action of Flavonoids From Licorice Against Methicillin-Resistant Staphylococcus aureus. Shuai-Cheng Wu, Zhi-Qiang Yang , Fei Liu , Wen-Jing Peng , Shao-Qi Qu , Qian Li , Xiang-Bin Song , Kui Zhu , Jian-Zhong Shen. s.l. : Front Microbiol, 2019 .

https://pubmed.ncbi.nlm.nih.gov/31749783/

 

39. Effect of GutGard in the Management of Helicobacter pylori: A Randomized Double Blind Placebo Controlled Study. Sreenivasulu Puram, Hyung Chae Suh, Seung Un Kim, Bharathi Bethapudi, Joshua Allan Joseph, Amit Agarwal, Venkateswarlu Kudiganti. s.l. : Evid Based Complement Alternat Med, 2013.

https://pubmed.ncbi.nlm.nih.gov/23606875/

 

40. Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests. Dinesh Dhingra, Amandeep Sharma. s.l. : Prog Neuropsychopharmacol Biol Psychiatry, 2006.

https://pubmed.ncbi.nlm.nih.gov/16443316/

 

41. Potentiating effect of glabridin from Glycyrrhiza glabra on GABA A receptors. Katrin M Hoffmann, Leopoldo Beltrán , Paul M Ziemba , Hanns Hatt , Günter Gisselmann. s.l. : Biochem Biophys Rep, 2016 .

https://pubmed.ncbi.nlm.nih.gov/29214227/

 

42. Potentiating effect of glabridin on GABAA receptor-mediated responses in dorsal raphe neurons. Zhenhua Jin, Sojin Kim, Suengmok Cho, In-Ho Kim, Daeseok Han, Young-Ho Jin. s.l. : Planta Med, 2013.

https://pubmed.ncbi.nlm.nih.gov/23975867/

 

43. Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy. A G Morgan, W A McAdam, C Pacsoo, A Darnborough. s.l. : Gut., 1982.

https://pubmed.ncbi.nlm.nih.gov/7042486/

 

44. Regulatory effects of glycyrrhizae radix extract on DSS-induced ulcerative colitis. Yong-Deok Jeon, Keuk-Soo Bang, Min-Kyoung Shin, Jong-Hyun Lee, Young-Nam Chang, and Jong-Sik Jincorresponding author. s.l. : BMC Complement Altern Med. , 2016.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111347/

 

45. Glycyrrhetic Acid Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Vivo. Yong-Deok Jeon, Sa-Haeng Kang , Keuk-Soo Bang , Young-Nam Chang , Jong-Hyun Lee , Jong-Sik Jin. s.l. : Molecules, 2016 .

https://pubmed.ncbi.nlm.nih.gov/27110761/

 

46. Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis. H-S Kwon, S-M Oh, J-K Kim. s.l. : Clin Exp Immunol. , 2008.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276918/

 

47. Metabolic changes after licorice consumption: A systematic review with meta-analysis and trial sequential analysis of clinical trials. Ângelo Luís, Fernanda Domingues , Luísa Pereira. s.l. : Phytomedicine, 2018.

https://pubmed.ncbi.nlm.nih.gov/29433679/

 

48. Changes of Insulin Resistance and Adipokines Following Supplementation with Glycyrrhiza Glabra L. Extract in Combination with a Low-Calorie Diet in Overweight and Obese Subjects: a Randomized Double Blind Clinical Trial. Mohammad Alizadeh, Nazli Namazi , Elham Mirtaheri , Nafiseh Sargheini , Sorayya Kheirouri. s.l. : Adv Pharm Bull, 2018.

https://pubmed.ncbi.nlm.nih.gov/29670847/

 

49. Mechanism of action of glycyrrhizic acid in inhibition of Epstein-Barr virus replication in vitro. Lin, Jung Chung. s.l. : Antiviral Res, 2003.

https://pubmed.ncbi.nlm.nih.gov/12834859/

 

50. The Effect of Aqueous Extract of Glycyrrhiza glabra on Herpes Simplex Virus 1. Masoud Sabouri Ghannad, Avid Mohammadi, Sohayla Safiallahy, Javad Faradmal,Mona Azizi, and Zohreh Ahmadvand. s.l. : Jundishapur J Microbiol. , 2014.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216581/

 

51. Anti-virus research of triterpenoids in licorice. Jie-Ying Pu, Li He , Si-Yu Wu , Ping Zhang , Xi Huang. s.l. : Bing Du Xue Bao, 2013.

https://pubmed.ncbi.nlm.nih.gov/24520776/

 

52. The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb. Liqiang Wang, Rui Yang, Bochuan Yuan, Ying Liu, Chunsheng Liu. s.l. : Acta Pharm Sin B. , 2015.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629407/

 

53. Efficacy and tolerability of anti-asthma herbal medicine intervention in adult patients with moderate-severe allergic asthma. Ming-Chun Wen, Chun-Hua Wei, Zhao-Qiu Hu, Kamal Srivastava, Jimmy Ko, Su-Ting Xi, Dong-Zhen Mu, Ji-Bin Du, Guo-Hua Li, Sylvan Wallenstein, Hugh Sampson, Meyer Kattan, Xiu-Min Li. s.l. : J Allergy Clin Immunol, 2005.

https://pubmed.ncbi.nlm.nih.gov/16159618/

 

54. Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. Susan Arentz, Caroline A Smith , Jason Abbott , Paul Fahey , Birinder S Cheema , Alan Bensoussan. s.l. : Phytother Res, 2017.

https://pubmed.ncbi.nlm.nih.gov/28685911/

 

55. Effect of TJ-68 (shakuyaku-kanzo-to) on polycystic ovarian disease. K Takahashi, M Kitao. s.l. : Int J Fertil Menopausal Stud, 1994;.

https://pubmed.ncbi.nlm.nih.gov/8012442/

56. Evaluation of contextual and demographic factors on licorice effects on reducing hot flashes in postmenopause women. Lida Menati, Khosheh Khaleghinezhad, Mitra Tadayon, Amir Siahpoosh. s.l. : Health Care Women Int, 2014.

https://pubmed.ncbi.nlm.nih.gov/23663094/

 

57. Effects of licorice on relief and recurrence of menopausal hot flashes. Fatemeh Nahidi, Elham Zare, Faraz Mojab, Hamid Alavi-Majd. s.l. : Iran J Pharm Res, 2012.

https://pubmed.ncbi.nlm.nih.gov/24250477/

 

58. Effectiveness of glycyrrhizin for oral lichen planus in patients with chronic HCV infection. Y Da Nagao, M Sata, H Suzuki, K Tanikawa, K Itoh, T Kameyama. s.l. : J Gastroenterol, 1996 .

https://pubmed.ncbi.nlm.nih.gov/8887036/

 

59. The efficacy of licorice root extract in decreasing transaminase activities in non-alcoholic fatty liver disease: a randomized controlled clinical trial. Ali Akbar Hajiaghamohammadi, Amir Ziaee, Rasoul Samimi. s.l. : Phytother Res, 2012 .

https://pubmed.ncbi.nlm.nih.gov/22308054/

 

60. Effects of the gap junction blocker glycyrrhetinic acid on gastrointestinal smooth muscle cells. Yukari Takeda, Sean M Ward, Kenton M Sanders, Sang Don Koh. s.l. : Am J Physiol Gastrointest Liver Physiol, 2005 .

https://pubmed.ncbi.nlm.nih.gov/15528254/

 

61. Reversible inhibition of intercellular junctional communication by glycyrrhetinic acid. J S Davidson, I M Baumgarten, E H Harley. s.l. : Biochem Biophys Res Commun, 1986.

https://pubmed.ncbi.nlm.nih.gov/3947327/

 

62. צמחי מרפא של ארץ ישראל, מאת פרופ׳ דן פלביץ׳ וד״ר זוהרה יניב

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עריכת מקורות: אלה ירושלמי

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